Family Based Directly Observed Therapy on Culture Conversion in Newly Diagnosed Pulmonary Tuberculosis Patients
Duangjai Duangrithi1, 2, , Kamol Phojanamongkolkij3, Vipa Thanachartwet2, Varunee Desakorn2, Yuthichai Kasetjaroen4, Pasakorn Jitruckthai5, Duangjai Sahassananda6 and Punnee Pitisuttithum2
1Department of Pharmacy Practice, Faculty of Pharmacy, Rangsit University, Pathumthani, Thailand
2Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Queen Sawang Vadhana Memorial Hospital, Chon Buri, Thailand
4Bureau of Tuberculosis, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
5Chon Buri Hospital, Chon Buri, Thailand
6Information Technology Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Pub. Date: July 30, 2014
Cite this paper
Duangjai Duangrithi, Kamol Phojanamongkolkij, Vipa Thanachartwet, Varunee Desakorn, Yuthichai Kasetjaroen, Pasakorn Jitruckthai, Duangjai Sahassananda and Punnee Pitisuttithum. Family Based Directly Observed Therapy on Culture Conversion in Newly Diagnosed Pulmonary Tuberculosis Patients.
American Journal of Public Health Research. 2014; 2(4):147-152. doi: 10.12691/AJPHR-2-4-4
Abstract
Background: The effectiveness of directly observed therapy (DOT) on TB treatment outcome has been debated and different findings regarding different DOT practices and settings were demonstrated. Methodology: The observational study was conducted in new sputum smear and culture positive pulmonary TB patients at Queen Savang Vadhana Memorial Hospital and Chonburi Hospital, Chonburi province, Thailand during April 2010 and July 2012. The aim of this study was to evaluate the effect of family based DOT toward sputum culture conversion. Sputum AFB smear, culture and drug susceptibility test were performed at the time of diagnosis, the second and the fifth month of treatment. Baseline characteristic, clinical and laboratory parameters, treatment regimens and adverse events were recorded. Descriptive statistics were applied as appropriate. Results: Proportion of patients with illiteracy, visual alteration and hepatitis was significantly higher in family based DOT group (p=0.026, p=0.011 and p=0.031). Sputum smear and culture conversion at 2 and 5 months after treatment were not significantly different between family based DOT and self administer groups. Patients in both group achieved over 90% cure rate without significant difference (p=0.262). Conclusions: Continuing patient education, counseling and AEs monitoring should be incorporated into family based DOT to achieved successful outcome. DOT can be interfered by many factors. Therefore appropriate implementing of DOT can enhance effectiveness of DOT toward patient adherence and further achieve success in TB treatment and control.
Keywords
DOT, family base DOT, culture conversion, new pulmonary TB
Copyright
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References
[1] | Volmink J, Garner P, “Directly observed therapy for treating tuberculosis,” Cochrane Database Syst Rev, CD003343, 2007. |
|
[2] | World Health Organization, The Stop TB Strategy Building on and enhancing DOTS to meet the TB-related Millennium Development Goals, 2006. 22p. |
|
[3] | Arnadottir T. Tuberculosis and Public Health. Policy and Principles in Tuberculosis Control, International Union Against Tuberculosis and Lung Disease, Paris, 2009, 547p. |
|
[4] | Okanurak K, Kitayaporn D, Wanarangsikul W, Koompong C, “Effectiveness of DOT for tuberculosis treatment outcomes: a prospective cohort study in Bangkok, Thailand,” The International Journal of Tuberculosis and Lung Disease, 11(7).762-768. 2007. |
|
[5] | Migliori G, Ambrosetti M, Besozzi G, Casali L, Raviglione M, “Prospective multicentre study on the evaluation of antituberculosis treatment results in Italy: comparison of the culture- versus the smear-based methods,” European Respiratory Journal, 13: 900-903. 1999. |
|
[6] | Vidal R, Martin-Casabona N, Juan A, Falgueras T, Miravitlles M, “Incidence and significance of acid-fast bacilli in sputum smears at the end of antituberculous treatment,” CHEST, 109:1562-5. 1996. |
|
[7] | World Health Organization, Treatment of tuberculosis: guidelines, 4th ed.: World Health Organization, Geneva, 2010, 147p. |
|
[8] | World Health Organization, Global tuberculosis report, World Health Organization, Geneva, 2012, 272p. |
|
[9] | Aït-Khaled N, Alarcón E, Armengol R, et al, Management of Tuberculosis, A Guide to the Essentials of Good Practice, International Union Against Tuberculosis and Lung Disease, Paris, 2010, 104p. |
|
[10] | Prapanwonge A, Rattanajiemrungsri S, Klinchan S, Tipayamongkholgul M, “Effects of DOT Observer for Tuberculosis Treatment in Mountainous Areas,” Asia Journal of Public Health, 2 (3): 9-14. Sep2011. |
|
[11] | Cavalcante SC, Soares ECC, Pacheco AGF, Chaisson RE, Durovni B, Team DE, “Community DOT for tuberculosis in a Brazilian favela: comparison with a clinic model,” The International Journal of Tuberculosis and Lung Disease 11 (5): 544-9. 2007. |
|
[12] | Ormerod LP, “Directly observed therapy (DOT) for tuberculosis: why, when, how and if?” Thorax, 54 Suppl 2: S42-5. 1999. |
|
[13] | Anuwatnonthakate A, Limsomboon P, Nateniyom S, et al. “Directly Observed Therapy and Improved Tuberculosis Treatment Outcomes in Thailand,” PLoS ONE, 3, e3089. 2008 |
|
[14] | Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J, “Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research,” PLoS Med, 4, e238. 2007. |
|
[15] | Widjanarko B, Gompelman M, Dijkers M, van der Werf MJ, “Factors that influence treatment adherence of tuberculosis patients living in Java, Indonesia” Patient preference and adherence, 3, 231-238. 2009. |
|