The Evidence-Based TaibUVID Nutritional Treatment for Minimizing COVID-19 Fatalities and Morbidity and eradicating COVID-19 pandemic: A novel Approach for Better Outcomes (A Treatment Protocol)

Salah Mohamed El Sayed^{1, 2,} , Hamdi H. Almaramhy³, Yasmeen Talal Aljehani⁴, Ahmed M. Okashah⁵, Mariam E. El-Anzi⁶, Mansour Barakah AlHarbi⁷, Rehab El-Tahlawi^{8, 9}, Manal Mohamed Helmy Nabo¹⁰, Moutasem Salih Aboonq¹¹, Osama Hamouda¹² and Osama Alhadramy¹³

¹Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

²Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt;Integrative Medicine and Prophetic Medicine Course and Research, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

³Department of surgery, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

⁴Family medicine programme & Ministry of Health Affairs & Sayed Al-Shuhada Primary Health Care Center, Al-Madinah Al-Munawwarah, Saudi Arabia

⁵Academic Affairs Director And Consultant Clinical Immunologist, Al-Madinah Directorate of Health, Al-Madinah Al-Munawwarah, Ministry of Health, Saudi Arabia

⁶Diabetic Center in King Fahd Hospital & Said Alshohada Primary Health Care Center, Al-Madinah Al-Munawwarah, Saudi Arabia

⁷Head of training and academic affairs and Designated Institutional Official (DIO), King Fahad Hospital, Al-Madinah and Leader of Training and Academic Affairs Taskforce, Al-Madinah Al-Munawwarah, Saudi Arabia

⁸Department of Microbiology, College of Medicine, Taibah University, Saudi Arabia

⁹0Department of Microbiology, Faculty of Medicine, Zagazig University, Egypt

¹⁰1Division of Pediatric Cardiology, Pediatrics Department, Maternity and children hospital, Hail, Saudi Arabia

¹¹2Department of Medical Physiology, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

¹²Integrative Medicine and Prophetic Medicine Course and Research, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

¹³3Division of Cardiology, Department of Medicine, Taibah College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

Cite this paper

Salah Mohamed El Sayed, Hamdi H. Almaramhy, Yasmeen Talal Aljehani, Ahmed M. Okashah, Mariam E. El-Anzi, Mansour Barakah AlHarbi, Rehab El-Tahlawi, Manal Mohamed Helmy Nabo, Moutasem Salih Aboonq, Osama Hamouda and Osama Alhadramy. The Evidence-Based TaibUVID Nutritional Treatment for Minimizing COVID-19 Fatalities and Morbidity and eradicating COVID-19 pandemic: A novel Approach for Better Outcomes (A Treatment Protocol). American Journal of Public Health Research. 2020; 8(2):54-60. doi: 10.12691/AJPHR-8-2-3

Abstract

With the continuously expanding terrible pandemic of COVID-19 infection, globally increasing numbers of COVID-19 patients and contacts progressively jump to heavy burdens beyond capabilities. Developing and poor countries may face humanity disasters in the next few days unless urgent measures are rapidly performed. Standard anti-COVID-19 treatment should inhibit COVID-19 replication, repair virus-induced tissue damage and enhance patients' immunity. Unfortunately, such criteria are still lacking in current treatments resulting in relatively high viral infectivity, morbidity and mortality. Based on previous prophetic medicine research experience and the modern literature, we introduce TaibUVID therapy as a novel evidence-based medicinal nutritional treatment for eradicating COVID-19 pandemic. TaibUVID stands for Taibah University anti-COVID-19 treatment as a novel evidence-based approach (using natural products) for treating COVID-19 patients. A single TaibUVID dose includes: 1 small spoonful (tea spoonful) of nigella sativa oil (or 2 gram nigella sativa seeds) mixed with 1 gram of grinded anthemis hyalina mixed with 1 large spoonful of natural honey. This mixture is to be chewed in the mouth and swallowed orally for both COVID-19 contacts and patients. We adjusted dosing regimen and period of treatment into three clinical levels including contacts or prophylaxis, mild cases and severe case (with pneumonia and ventilated patients). We also introduce novel nigella sativa oil (or nigella sativa decoction) nebulization for local treatment of pneumonia or bronchopneumonia that is faced in severe COVID-19 cases. Such nebulization exerts pulmonary tissue protection and antiviral effects particularly for ventilated patients. The wonderful report by Ulasli et al. (Ulasli et al. Mol Biol Rep. 2014; 41: 1703-11) deserves a lot of interest where nigella sativa and Anthemis hyalina (chamomile) were confirmed to inhibit corona virus replication maximally. In addition, nigella sativa enhances immunity, exerts tissue protective effects and effectively treats co-morbidities. Oral honey exerts potent antiviral effects, enhances immunity and exerts tissue protective effects. TaibUVID Plus dose includes regular TaibUVID dose plus nigella sativa decoction nebulization ± (if possible Clove oil nebulization/ anthemis hyalina decoction nebulization). Clove oil nebulization is beneficial for difficult berating in some COVID-19 cases as clove is confirmed to exert potent antiviral effects. Our suggested TaibUVID and TaibUVID Plus are promising evidence-based approach to rescue lives, decrease fatalities and put a rapid end to COVID-19 pandemic. In prophetic medicine, Prophet Muhammad peace be upon him recommended treatment using both nigella sativa and oral honey saying: " In the black cumin (nigella sativa), there is a cure for every disease except death" and said also: "Cure is in three: in shartat mihjam, gulp of honey (oral honey), and cauterization. I do not recommend my nation to cauterize".

Keywords

COVID-19, TaibUVID, nigella sativa, anthemis hyalina, oral honey and citrus sinensis

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References

[1]	Ulasli M, Gurses SA, Bayraktar R, Yumrutas O, Oztuzcu S, Igci M, Igci YZ, Cakmak EA, Arslan A.The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family. Mol Biol Rep. 2014 Mar;41(3):1703-11.
[2]	Perlman S, Netland J (2009) Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol 7:439-450.
[3]	Sawicki SG, Sawicki DL, Siddell SG (2007) A contemporary view of coronavirus transcription. J Virol 81:20-29.
[4]	Wijegoonawardane PK, Cowley JA, Phan T, Hodgson RA, Nielsen L, Kiatpathomchai W, Walker PJ (2008) Genetic diversity in the yellow head nidovirus complex. Virology 380:213-225.
[5]	Brian DA, Baric RS (2005). Coronavirus genome structure and replication. Curr Top Microbiol Immunol 287:1-30.
[6]	Lai MM, Cavanagh D (1997). The molecular biology of coronaviruses. Adv Virus Res 48: 1-100.
[7]	Barcena M, Oostergetel GT, Bartelink W, Faas FG, Verkleij A, Rottier PJ, Koster AJ, Bosch BJ (2009) Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion. Proc Natl Acad Sci USA 106:582-587.
[8]	Davies HA, Macnaughton MR (1979) Comparison of the morphology of three coronaviruses. Arch Virol 59:25-33.
[9]	de Haan CA, Rottier PJ (2005) Molecular interactions in the assembly of coronaviruses. Adv Virus Res 64:165-230.
[10]	Masters PS (2006) The molecular biology of coronaviruses. Adv Virus Res 66:193-292.
[11]	Drosten C, Gunther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguiere AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Muller S, Rickerts V, Sturmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW (2003) Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 348:1967-1976.
[12]	Liang G, Chen Q, Xu J, Liu Y, Lim W, Peiris JS, Anderson LJ, Ruan L, Li H, Kan B, Di B, Cheng P, Chan KH, Erdman DD, Gu S, Yan X, Liang W, Zhou D, Haynes L, Duan S, Zhang X, Zheng H, Gao Y, Tong S, Li D, Fang L, Qin P, Xu W (2004) Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province. China. Emerg Infect Dis 10: 1774-1781.
[13]	Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA (2012) Isolation of a novel corona virus from a man with pneumonia in Saudi Arabia. N Engl J Med 367:1814-1820.
[14]	Goh GK, Dunker AK, Foster JA, Uversky VN.Goh GK, et al. Biomolecules. Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity. 2020 Feb 19; 10(2): 331.
[15]	Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013 May; 3(5): 337-52.
[16]	Boskabady MH, Farhadi J. The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008 Nov; 14(9): 1137-44.
[17]	Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010 Aug; 17(10): 707-13.
[18]	Işik H, Cevikbaş A, Gürer US, Kiran B, Uresin Y, Rayaman P, Rayaman E, Gürbüz B, Büyüköztürk S. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010; 19(3): 206-11.
[19]	Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003 Dec; 17(10): 1209-14.
[20]	Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013 Apr 28; 19(16): 2529-36.
[21]	Onifade AA, Jewell AP, Adedeji WA.Onifade AA, et al. Nigella sativa concoction induced sustained seroreversion in HIV patient. Afr J Tradit Complement Altern Med. 2013 Aug 12; 10(5): 332-5. eCollection 2013.
[22]	Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009 Jun; 15(6): 639-44.
[23]	Bamosa AO1, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A.Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2010 Oct-Dec; 54(4): 344-54.
[24]	Najmi A, Nasiruddin M, Khan RA, Haque SF. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev Ctries. 2008 Jan; 28(1): 11-4.
[25]	Bamosa A, Kaatabi H, Badar A, Al-Khadra A, Al Elq A, Abou-Hozaifa B, Lebda F, Al-Almaie S. Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus. J Family Community Med. 2015 May-Aug;22(2): 88-95.
[26]	Leong XF, Rais Mustafa M, Jaarin K.Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension. Evid Based Complement Alternat Med. 2013; 2013: 120732.
[27]	Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug; 26(8): 1246-8.
[28]	Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol. 2011 Sep-Oct; 32(5): 402-7.
[29]	Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA. Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol. 2010 Jul-Sep; 16(3): 207-14.
[30]	Dwarampudi LP, Palaniswamy D, Nithyanantham M, Raghu PS. Antipsoriatic activity and cytotoxicity of ethanolic extract of Nigella sativa seeds. Pharmacogn Mag. 2012 Oct; 8(32): 268-72
[31]	Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol. 2007 Oct; 21(5): 559-66.
[32]	Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010 Aug; 17(10): 707-13.
[33]	Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR. The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 2013 Jul 30; 148(3): 780-6.
[34]	Yaghoobi R, Kazerouni A, Kazerouni O.Yaghoobi R, et al. Evidence for Clinical Use of Honey in Wound Healing as an Anti-bacterial, Anti-inflammatory Anti-oxidant and Anti-viral Agent: A Review. Jundishapur J Nat Pharm Prod. 2013 Aug; 8(3): 100-4.
[35]	Münstedt K. Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review. Complement Ther Med. 2019 Apr; 43: 81-84.
[36]	Al-Waili NS. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Med Sci Monit. 2004; 10(8): MT94-8.
[37]	Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N.Watanabe K, et al. Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey. Arch Med Res. 2014 Jul; 45(5): 359-65
[38]	Abdel-Naby Awad OG, Hamad AH. Abdel-Naby Awad OG, et al. Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial. Am J Otolaryngol. 2018 Nov-Dec; 39(6): 759-763.